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ALS

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), Lou Gehrig's disease or Charcot's disease, is a rare terminal neurodegenerative disease defined by the progressive loss of both upper and lower motor neurons that normally control voluntary muscle contraction. ALS is the most common of the motor neuron diseases. ALS often presents with gradual muscle stiffness, twitches, weakness, and wasting. Motor neuron loss typically continues until the ability to eat, speak, move, and breathe without mechanical support is lost. At least 50% of people with ALS experience significant changes in thinking and behavior, with 15% of individuals going on to develop frontotemporal dementia. An ALS diagnosis is made based on a person's signs and symptoms, with additional testing conducted to rule out other potential causes. Depending on which areas of the body are affected first, ALS may be classified as limb-onset or bulbar-onset. Respiratory onset occurs in approximately 1–3% of cases.

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187trials recruiting now
United Statesmost trial sites (77)
283mapped site locations
Neuralink Corpmost active sponsor

Trials by phase

  • Early phase 14
  • Phase 124
  • Phase 225
  • Phase 37
  • Phase 41
  • Not applicable (device/behavioral)73
  • Observational study69

Phase 1 tests safety, phase 2 tests whether it works, phase 3 compares it with standard care, phase 4 follows it after approval.

Countries with the most trials

  • United States77
  • France20
  • Italy20
  • Germany16
  • Canada15
  • China14
  • Belgium13
  • Netherlands13

Where trials are recruiting

Each dot is a site city; bigger dots have more recruiting trials. Showing up to 400 locations.

Lead sponsors

Neuralink Corp · 6University of Pennsylvania · 4Leigh R. Hochberg, MD, PhD. · 4Johns Hopkins University · 4Istituto Auxologico Italiano · 4Penn State University · 3Hadassah Medical Organization · 3Eli Lilly and Company · 3

Newest recruiting trials

See all 187 on ClinicalTrials.gov →

General information only, not medical advice. Trial listings are written by sponsors; eligibility and contacts are on each official listing.