Live

Autism

Autism, also known as autism spectrum disorder (ASD), is a condition characterized by impairment in social communication and interaction, as well as a need or strong preference for predictability and routine, sensory processing differences, focused interests, or repetitive behaviors. Features of autism are present from early childhood and the condition typically persists throughout life. Autism is classified as a neurodevelopmental disorder, and a diagnosis requires professional assessment that these characteristics cause significant challenges in daily life beyond what is expected given a person's age and social environment. Because autism is a spectrum disorder, presentations vary and support needs range from minimal assistance to full-time, 24-hour care.

Trials by phase

Early phase 15
Phase 17
Phase 227
Phase 310
Phase 44
Not applicable (device/behavioral)226
Observational study80

Phase 1 tests safety, phase 2 tests whether it works, phase 3 compares it with standard care, phase 4 follows it after approval.

Countries with the most trials

United States159
France37
China25
Italy18
Taiwan18
Hong Kong15
Canada11
Pakistan10

Where trials are recruiting

Each dot is a site city; bigger dots have more recruiting trials. Showing up to 400 locations.

Lead sponsors

Stanford University · 16National Taiwan University Hospital · 13Riphah International University · 9Children's Hospital of Fudan University · 6Children's Hospital Medical Center, Cincinnati · 6The Hong Kong Polytechnic University · 6Assistance Publique - Hôpitaux de Paris · 6Istituto per la Ricerca e l'Innovazione Biomedica · 5

Newest recruiting trials

Not applicable (device/behavioral)
Regulating Together for Intellectual Disability and Autism: A Group Behavioral Therapy for for Emotion Dysregulation

NCT07624448 · started 2027-10 · Children's Mercy Hospital Kansas City · 10 participants · 1 site (United States)

Testing: Regulating Together group therapy
Not applicable (device/behavioral)
Effectiveness of Clown Therapy in Facilitating Dental Visits for Children With Autism Spectrum Disorder

NCT07906288 · started 2026-11-10 · University of Milan · 46 participants · 1 site (Italy)

Testing: Familiarization sessions using clown therapy · Familiarization sessions with conventional methods
Phase 2
Heart Rate Variability Biofeedback for Anxiety in Autistic Youth

NCT07812233 · started 2026-10-26 · Massachusetts General Hospital · 50 participants · 1 site (United States)

Testing: Lief Smart Patch
Observational study
Effectiveness of the Autism Pupil Screen (APS) Detect Pupillometer for Identifying Autism Spectrum Disorder (ASD) in Routine Healthcare

NCT07903675 · started 2026-10-23 · Schweitzer Engineering Laboratories · 330 participants · 4 sites (United States)

Testing: Autism Pupil Screen (APS) Detect PLR Assessment #1 · Modified Checklist for Autism in Toddlers, Revised with Follow-up (M-CHAT/R-F) · Social Responsiveness Scale, Second Edition (SRS-2)
Phase 4
Semaglutide in Youth With Autism Spectrum Disorder

NCT07770152 · started 2026-10-18 · Children's Hospital Medical Center, Cincinnati · 42 participants · 1 site (United States)

Testing: Glucagon-like peptide-1 receptor agonist：Semaglutide · Lifestyle Management (LSM) Counseling
Phase 3
A Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism Spectrum Disorder

NCT07285798 · started 2026-10-06 · Bristol-Myers Squibb · 176 participants · 67 sites (France, Germany, Hungary, India)

Testing: KarXT · KarX-EC · KarXT + KarX-EC Matching Placebo
Phase 3
A Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism

NCT07284745 · started 2026-10-06 · Bristol-Myers Squibb · 176 participants · 41 sites (Australia, Canada, Puerto Rico, United States)

Testing: KarXT · KarX-EC · KarXT + KarX-EC Matching Placebo
Not applicable (device/behavioral)
A Comparative Study of Driving Performance Among Adolescents With Autism Spectrum Disorder and Neurotypical Adolescents

NCT07630298 · started 2026-10-05 · Hopital La Musse · 22 participants · 1 site (France)

Testing: Assessment of executive functions and attention · Evaluation on a driving simulator · Evaluation on-road
Phase 2
TRIal of PPF3 vs. PlaCEbo in the TReatment of Children and AdolescenTs With NeurOdeveloPmental DisorderS

NCT07893964 · started 2026-10 · Holland Bloorview Kids Rehabilitation Hospital · 100 participants · 4 sites (Canada)

Testing: PPF3 · Placebo
Not applicable (device/behavioral)
To Share or Not To Share: Navigating Disclosure and Stigma Among Family Caregivers of Autistic Young Adults_Group Intervention

NCT07856927 · started 2026-09-17 · University of Wisconsin, Madison · 50 participants · 1 site (United States)

Testing: Group Intervention
Observational study
Decoding Central Defects in Dystrophinopathies From Diagnostic to Remediation

NCT07125898 · started 2026-09-16 · Assistance Publique - Hôpitaux de Paris · 110 participants · 1 site (France)
Not applicable (device/behavioral)
Safety and Efficacy of NDTx-03 in Children and Adolescents With ASD or SCD

NCT07770867 · started 2026-09-15 · Neudive Inc. · 156 participants · 7 sites (South Korea)

Testing: NDTx-03 · TAU
Not applicable (device/behavioral)
Evaluating a Workbook to Promote Autistic Wellbeing

NCT07630376 · started 2026-09-01 · Canterbury Christ Church University · 10 participants · 1 site (United Kingdom)

Testing: Guided self-help workbook for autistic adults
Phase 4
Buspirone for Anxiety in Autistic Youth

NCT07439042 · started 2026-09 · Massachusetts General Hospital · 20 participants · 1 site (United States)

Testing: buspirone · Placebo
Not applicable (device/behavioral)
Dialectic Behaviour Therapy (DBT) for People With Autism: A Multiple Baseline Single Case Design

NCT07786883 · started 2026-09 · GGZ Friesland · 6 participants · 1 site (Netherlands)

Testing: Dialectic Behavioural Therapy
Not applicable (device/behavioral)
Structured Sensory-Based Occupational Therapy in Children With Autism

NCT07789704 · started 2026-08-28 · Emre DANSUK · 40 participants · 1 site (Turkey (Türkiye))

Testing: Structured Sensory-Based Occupational Therapy · Individualized Home Activity Program
Not applicable (device/behavioral)
Social Robots and Board Games for Children With Autism Spectrum Disorder

NCT07775937 · started 2026-08-18 · National Taiwan University Hospital · 20 participants · 1 site (Taiwan)

Testing: Social Robot-Assisted Board Game Intervention · Conventional Occupational Therapy
Not applicable (device/behavioral)
Behavioral Activation for Treatment of Depression in Autistic Adolescents With Below Average Intelligence

NCT07812870 · started 2026-08-10 · Stony Brook University · 18 participants · 1 site (United States)

Testing: BA-A
Not applicable (device/behavioral)
Smart Inhaler and Remote Asthma Management in Adolescents With Intellectual and Developmental Disabilities

NCT07746921 · started 2026-08-10 · Children's Hospital Los Angeles · 34 participants · 1 site (United States)

Testing: Use of active remote smart inhaler in the home setting · Use of passive remote smart inhaler in the home setting
Observational study
This Study Will Evaluate Cardiorespiratory and Muscular Fitness to Examine Associations With Anthropometric Characteristics and Other Indicators of Cardiometabolic Risk Among Patients With or Without Autism Spectrum Disorder

NCT07804680 · started 2026-08-05 · University of Virginia · 200 participants · 1 site (United States)
Early phase 1
Prednisone in Adults With an Immune-Mediated Subtype of Autism Spectrum Disorder

NCT06934915 · started 2026-08-01 · Christopher John McDougle, M.D. · 32 participants · 1 site (United States)

Testing: Prednisone · Placebo
Not applicable (device/behavioral)
Clinical Trial of "Exploradores de Sabores" to Improve Food Selectivity in ASD Kids

NCT07727018 · started 2026-08 · Universidad Autonoma de Baja California · 72 participants · 1 site (Mexico)

Testing: Exploradores de Sabores Parent-Mediated Nutrition Intervention · Education as Usual (EAU)
Not applicable (device/behavioral)
Transitional Intervention for Hyperacusis in Autism

NCT07798297 · started 2026-08 · University of Central Florida · 40 participants · 2 sites (United States)

Testing: Transitional Intervention for Hyperacusis in Autism
Not applicable (device/behavioral)
Differences in Rest, Emotion, and Arousal Modulation in Youth

NCT07476937 · started 2026-07-20 · University of Pittsburgh · 60 participants · 1 site (United States)

Testing: Power Down bedtime manipulation
Not applicable (device/behavioral)
Characterization of the Natural History of Microduplication Syndrome 7q11.23

NCT07469566 · started 2026-07-15 · Hospices Civils de Lyon · 15 participants · 2 sites (France)

Testing: clinical assessment · Parental questionnaires · Cognitive assessment

See all 355 on ClinicalTrials.gov →

General information only, not medical advice. Trial listings are written by sponsors; eligibility and contacts are on each official listing.