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Heart failure

Heart failure (HF), also known as congestive heart failure (CHF), is a syndrome caused by an impairment in the heart's ability to fill with and pump blood.

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1,021trials recruiting now

United Statesmost trial sites (328)

400+mapped site locations

Mayo Clinicmost active sponsor

Newest recruiting trials

• Not applicable (device/behavioral)

  AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure

  NCT06650995 · started 2027-02-01 · Technical University of Munich · 40 participants · 1 site (Germany)

  Testing: Exercise training

• Observational study

  Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

  NCT07083557 · started 2027-01-01 · Bettina Mittendorfer · 100 participants · 1 site (United States)

  Testing: Endothelial cell collection

• Phase 1

  Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pulmonary Hypertension

  NCT06770023 · started 2026-12-11 · Mayo Clinic · 4 participants · 1 site (United States)

  Testing: Protek Solo Transseptal Cannula

• Phase 4

  Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score

  NCT07490067 · started 2026-12 · University of Michigan · 100 participants · 1 site (United States)

  Testing: Metoprolol Succinate · Beta-Blocker Polygenic Score · Illumina Infinium Global Diversity Array with Enhanced Pharmacogenomics (PGx)

• Observational study

  AI-Based Cardiac Analysis Using 12-Lead and 1-Lead ECG

  NCT07844434 · started 2026-11-10 · Inha University Hospital · 300 participants · 1 site (South Korea)

  Testing: SmartECG-EF

• Phase 2

  Reversing Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction

  NCT06217120 · started 2026-11-06 · Montreal Heart Institute · 64 participants · 1 site (Canada)

  Testing: Colchicine · Placebo

• Phase 2

  The Clinical Trial of Tamibarotene for Patients With HFpEF (RELIEF Trial)

  NCT07855692 · started 2026-11-05 · Nagoya University · 90 participants · 4 sites (Japan)

  Testing: Tamibarotene · Placebo

• Not applicable (device/behavioral)

  BRIDGE Trial: Embedding Consumer-grade mHealth Technologies Into Cardiac Rehabilitation

  NCT07741396 · started 2026-11-02 · University of Illinois Chicago · 30 participants · 1 site (United States)

  Testing: CBCR · BRIDGE mHealth intervention

• Observational study

  Association Between Sleep Quality and Self-Care in Heart Failure Patients

  NCT06747689 · started 2026-11-01 · Dokuz Eylul University · 207 participants · 1 site (Turkey (Türkiye))

• Not applicable (device/behavioral)

  PrEcision Pacing in HFpEF: the PEP-HFpEF Trial

  NCT07864558 · started 2026-11 · Tufts Medical Center · 36 participants · 1 site (United States)

  Testing: Individualized myPACE pacemaker programming

• Observational study

  Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction

  NCT07401771 · started 2026-11 · Mayo Clinic · 400 participants · 1 site (United States)

  Testing: Exercise Cardiovascular Magnetic Resonance

• Not applicable (device/behavioral)

  Routine Microaxial Heart Pump Support and Protocolized Pulmonary Artery Catheter Monitoring Versus Standard Care in Heart Attack-Related Cardiogenic Shock

  NCT07762560 · started 2026-10-31 · Leipzig Heart Science gGmbH · 780 participants · 1 site (Germany)

  Testing: Microaxial flow pump (left ventricular assist device) · Pulmonary artery catheter · Conventional hemodynamic monitoring

• Not applicable (device/behavioral)

  Artificial Voice Analysis and Telemonitoring for Heart Failure. A Feasibility Study

  NCT07664748 · started 2026-10-30 · Niguarda Hospital · 60 participants · 1 site (Italy)

  Testing: AVATAR-SC · Levosimendan

• Not applicable (device/behavioral)

  Evaluation of a French Hospital Discharge Therapeutic Education Program by Nurses for Heart Failure Patient (EduSor)

  NCT07706543 · started 2026-10-29 · University Hospital, Clermont-Ferrand · 412 participants · 3 sites (France)

  Testing: Nurse-led discharge education

• Not applicable (device/behavioral)

  PRECISE-AFMR I: Transcatheter Mitral Valve Edge-to-Edge Repair for Atrial Functional Mitral Regurgitation in Patients at High Surgical Risk

  NCT07741253 · started 2026-10-25 · China National Center for Cardiovascular Diseases · 182 participants · 1 site (China)

  Testing: Transcatheter Edge-to-Edge Repair

• Phase 1, Phase 2

  HS235 Study in Overweight and Obese Participants With Combined Pre and Post-Capillary Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction

  NCT07123779 · started 2026-10-21 · 35Pharma Inc., a GSK company · 126 participants · 3 sites (United States)

  Testing: HS235 · Placebo

• Not applicable (device/behavioral)

  Effects of a Specialized Diabetes and Heart Clinic and Detection of Unrecognized Heart Failure in People With Type 2 Diabetes and Cardiovascular Disease

  NCT07878325 · started 2026-10-20 · Odense University Hospital · 375 participants · 1 site (Denmark)

  Testing: Cardio-Metabolic Clinic

• Not applicable (device/behavioral)

  Evaluating a Digital Aid to Improve ICD Decisions

  NCT07913204 · started 2026-10-19 · Stanford University · 600 participants · 2 sites (United States)

  Testing: Arm A: Online, patient-facing decision-making aid (app) with personalized risk information. · Arm B - Online, patient-facing decision-making app without personalized risk information. · Arm C - Usual Care/No Device

• Observational study

  Voice-based Outcome Identification and Clinical Evaluation in Heart Failure

  NCT07870395 · started 2026-10-15 · Noah Labs · 450 participants · 1 site (United States)

  Testing: Daily Voice Recording

• Not applicable (device/behavioral)

  Bundle Branch Pacing to Preserve Ejection Fraction in Atrial Fibrillation Trial

  NCT07759700 · started 2026-10-15 · Poitiers University Hospital · 642 participants · 1 site (France)

  Testing: LBBA pacing · Conventional pacing

• Phase 3

  SWITCH: Apixaban vs Vitamin K in HM3

  NCT07471139 · started 2026-10-15 · Columbia University · 460 participants · 1 site (United States)

  Testing: Warfarin · Apixaban

• Not applicable (device/behavioral)

  Achieving Optimal Medical Therapy Through Percutaneous Treatment of Secondary Mitral Regurgitation to Improve Outcome in Patients With HFrEF

  NCT07758023 · started 2026-10-15 · University Medical Center Mainz · 520 participants · 1 site (Germany)

  Testing: M-TEER · Standardized GDMT Up-Titration

• Not applicable (device/behavioral)

  Rehabilitation Program for People With Methamphetamine-Associated Cardiopulmonary Conditions

  NCT07915882 · started 2026-10-13 · Michael Incze · 45 participants · 1 site (United States)

  Testing: Increasing control over stimulant use and physical health through incentivized rehabilitation · Usual Care

• Not applicable (device/behavioral)

  Advancing Clinical Heart Failure Outcomes Leveraging Defibrillation Lead Implant System for Left Bundle Branch Area Pacing

  NCT07526896 · started 2026-10-13 · Medtronic Cardiac Rhythm and Heart Failure · 110 participants · 1 site (United States)

  Testing: LBBAP Therapy · LOT-CRT · ICD

• Phase 3

  Finerenone in Patients Undergoing Transcatheter Aortic Valve Implantation With Heart Failure

  NCT07575672 · started 2026-10-09 · Second Affiliated Hospital, Zhejiang University, School of Medicine · 2,832 participants · 61 sites (China)

  Testing: Finerenone · Placebo

See all 1,021 on ClinicalTrials.gov →