Lupus
Lupus, formally called systemic lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. Symptoms vary among people and may be mild to severe. Common symptoms include painful and swollen joints, fever, chest pain, hair loss, mouth ulcers, swollen lymph nodes, feeling tired, and a red rash which is most commonly on the face. Often there are periods of illness, called flares, and periods of remission during which there are few symptoms. Children up to 18 years old develop a more severe form of SLE termed childhood-onset systemic lupus erythematosus.
Trials by phase
Phase 1 tests safety, phase 2 tests whether it works, phase 3 compares it with standard care, phase 4 follows it after approval.
Countries with the most trials
Where trials are recruiting
Each dot is a site city; bigger dots have more recruiting trials. Showing up to 400 locations.
Lead sponsors
Newest recruiting trials
- Phase 1
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for Lupus
- Observational study
Pain Phenotyping of Rheumatic Diseases - An Observational Study
- Observational study
Deciphering the Genetic Architecture of Autoimmune Diseases
- Phase 1
Evaluating the Safety and Tolerability of Baricitinib in Patients With Job Syndrome With Lupus-Like Disease and/or Atopic Dermatitis
- Phase 2, Phase 3
Study of Afimetoran in Adults With Cutaneous Lupus Erythematosus
- Phase 1
To Evaluate the Effects of Cevostamab in Participants With Systemic Lupus Erythematosus With or Without Active Lupus Nephritis
- Phase 3
A Long-Term Extension (LTE) Study Of Enpatoran In Cutaneous Manifestations Of Lupus With Or Without Systemic Disease [Elowen-LTE]
- Not applicable (device/behavioral)
Lupus Nephritis Care Pathway
- Phase 1, Phase 2
FT839 in Autoimmune Diseases
- Observational study
Biopsychosocial Risk Influences on the Development and Generation of Early-Onset Chronic Pain
- Phase 1
A Study of ATG-201 in Adult Participants With Autoimmune Diseases
- Phase 1
A Trial in Healthy Adult Participants and Adults With Autoimmune Diseases to Test How HBM7020 is Tolerated and How it Behaves in the Body
- Phase 1, Phase 2
Study to Evaluate the Safety and Preliminary Efficacy of CD19 CAR-T Cell Therapy (TranspoCART19) in Patients With Refractory Lupus Nephritis
- Phase 1
CD19 CAR-T Therapy for Refractory Childhood-Onset Systemic Lupus Erythematosus
- Not applicable (device/behavioral)
HEALTH Home Urinalysis Testing
- Early phase 1
Safety and Efficacy of ONT01 in Lupus
- Phase 2
A Phase IIa Study of ICG318 CAR-T in Refractory Systemic Lupus Erythematosus With or Without Lupus Nephritis
- Phase 2
A Study to Investigate Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Anifrolumab in Pediatric Participants 5 to < 18 Years of Age With Systemic Lupus Erythematosus
- Phase 3
Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued Treatment
- Phase 3
A Study of Outcomes in Chinese Patients Treated With Anifrolumab Who Have Active Mod-severe Systemic Lupus Erythematosus
- Phase 1, Phase 2
A Study to Test CRT-402 in Refractory Autoimmune Disease
- Phase 1
A Study on the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Single Dose of SHR-7012 in Healthy Adults
- Not applicable (device/behavioral)
Gyrotonic Exercise in Lupus Adolescents Who Survived From Intensive Care
- Phase 2
A Phase 2 Study to Evaluate the Safety, PD, PK, and Clinical Activity of ADX-097 in Participants With IgAN, LN or C3G
- Phase 2
A Phase 2, Open-Label, Single-Arm Trial of FT819 in Participants With Lupus Nephritis
See all 325 on ClinicalTrials.gov →