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Parkinson's disease

Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor and non-motor systems. The motor symptoms, collectively called parkinsonism, include tremors, slowness in initiating movement (bradykinesia), rigidity, and difficulty maintaining balance. Non-motor symptoms may appear at any stage of the disease, including autonomic nervous system failures (dysautonomia), sleep abnormalities, decreased ability to smell (anosmia), and behavioral changes or neuropsychiatric problems, such as cognitive impairment, psychosis, and anxiety. Symptoms typically develop gradually, and non-motor issues become more prevalent as the disease progresses.

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508trials recruiting now
United Statesmost trial sites (170)
400+mapped site locations
University of Minnesotmost active sponsor

Trials by phase

  • Early phase 18
  • Phase 143
  • Phase 243
  • Phase 312
  • Phase 49
  • Not applicable (device/behavioral)263
  • Observational study147

Phase 1 tests safety, phase 2 tests whether it works, phase 3 compares it with standard care, phase 4 follows it after approval.

Countries with the most trials

  • United States170
  • China64
  • Italy39
  • Turkey (Türkiye)35
  • United Kingdom33
  • France30
  • Germany27
  • Canada24

Where trials are recruiting

Each dot is a site city; bigger dots have more recruiting trials. Showing up to 400 locations.

Lead sponsors

University of Minnesota · 10VA Office of Research and Development · 8Xiangya Hospital of Central South University · 7Michael J. Fox Foundation for Parkinson's Research · 7University of Alabama at Birmingham · 6Insel Gruppe AG, University Hospital Bern · 6AbbVie · 6Medical University of South Carolina · 6

Newest recruiting trials

See all 508 on ClinicalTrials.gov →

General information only, not medical advice. Trial listings are written by sponsors; eligibility and contacts are on each official listing.